The intellectual disability protein PAK3 regulates oligodendrocyte precursor cell differentiation
Oligodendrocyte and myelin deficits have been reported in mental/psychiatric diseases.The p21-activated kinase 3 (PAK3), a serine/threonine kinase, whose activity is stimulated by the Toy Instruments binding of active Rac and Cdc42 GTPases is affected in these pathologies.Indeed, many mutations of Pak3 gene have been described in non-syndromic inte